At ADRES, we provide comprehensive regulatory and quality assurance support for medical device companies, helping them achieve compliance with FDA, EU MDR, and other global regulatory frameworks. Our experts guide you through every stage of the regulatory process, ensuring a seamless pathway from product development to market approval.
Our Services
1. Regulatory Compliance
Our regulatory specialists help you navigate complex medical device regulations, ensuring your products meet all necessary requirements for global market entry.
- FDA and EU MDR Compliance – Guidance on FDA, EU MDR, and international regulatory frameworks.
- Pre-Market Submissions – Support for FDA 510(k), PMA, De Novo, and CE marking applications.
- Regulatory Strategy & Pre-Submission Support – Request for Designation (RFD), FDA Pre-Submissions, and discussions with Notified Bodies (NBs).
- ISO 13485 Consulting – Implementation and certification guidance for global QMS compliance.
- Risk Management – Ensuring ISO 14971 compliance with structured risk management processes.
2. Quality Management Systems (QMS)
Develop a robust and compliant QMS that aligns with regulatory expectations and enhances operational efficiency.
- QMS Design & Implementation – Tailored systems to meet ISO 13485, FDA QSR, and MDR standards.
- CAPA Implementation & Root Cause Analysis – Proactive quality control to address compliance gaps.
- Internal and Third-Party Audits – Ensure supplier and internal compliance readiness.
3. Product Development & Risk Management
Enhance product safety, performance, and regulatory approval success with structured risk management and usability evaluations.
- Usability Engineering & IEC 62366 Compliance – Human factors consulting for safer, user-friendly devices.
- Risk Analysis (FMEA) & Design Controls – Comprehensive assessment to mitigate potential failures.
- Design Documentation & Compliance Readiness – Preparation of Design History Files (DHF), gap analysis, and regulatory submissions.
- Biocompatibility Planning & Reporting – Strategic support in biological evaluation planning and execution.
4. Regulatory & Technical Writing Services
Our expert regulatory writers ensure clear, compliant, and high-quality documentation for both FDA and EU MDR submissions.
- Regulatory Submissions – FDA 510(k), PMA, De Novo applications, and EU Technical Files.
- Safety & Performance Reporting – SSCP, General Safety and Performance Requirements (GSPR), and Biocompatibility Evaluations.
- Post-Market Surveillance (PMS) & Clinical Follow-Up (PMCF, PSURs) – Ongoing compliance monitoring and reporting.
- Risk Management & Design Documentation – Development of risk management plans, design inputs/outputs, and traceability matrices.
- Clinical & Scientific Writing – Literature reviews, clinical study protocols, investigator brochures, and informed consent forms.
- Standard Operating Procedures (SOPs) & Quality Manuals – Ensure operational consistency and compliance readiness.
5. Training & Workshops
We offer customized training programs to keep your team updated on regulatory requirements and best practices.
- Regulatory & QMS Training – Hands-on workshops covering FDA, MDR, and ISO standards.
- Data Integrity & Documentation Best Practices – Ensure accuracy and compliance in medical device records.
- Regulatory Trends & Updates – Stay ahead of evolving regulations and industry expectations.
1. What is the difference between FDA 510(k), PMA, and De Novo pathways?
The 510(k) process is for demonstrating substantial equivalence to a legally marketed device. PMA (Pre-Market Approval) is required for high-risk Class III devices, and De Novo is for novel devices with no predicate.
2. What are the key requirements for CE marking in the EU?
CE marking requires compliance with EU MDR, including a conformity assessment, technical documentation, risk management, and clinical evaluation to demonstrate safety and performance.
3. How long does it take to get FDA approval for a medical device?
Approval timelines vary: 510(k) reviews typically take 3-6 months, De Novo can take 6-12 months, and PMA can take over a year, depending on complexity and FDA interactions.
4. What is ISO 13485, and why is it important?
ISO 13485 is the international standard for medical device quality management systems (QMS). It ensures regulatory compliance, risk management, and process control for device manufacturers.
5. Do all medical devices require clinical trials?
Not all devices require clinical trials. Low-risk devices may rely on existing data, while high-risk devices (Class III) often require clinical evidence for approval.
6. What is post-market surveillance (PMS), and why is it necessary?
PMS involves monitoring a device's performance after market approval to detect safety issues, adverse events, and ensure compliance with regulatory requirements like PMCF and PSURs.
7. How can ADRES help with regulatory submissions?
ADRES provides end-to-end support for FDA and EU submissions, including regulatory strategy, document preparation, risk analysis, and interaction with regulatory bodies.
8. How are medical devices classified under FDA and EU MDR?
Medical devices are classified based on risk:
- FDA: Class I (low risk), Class II (moderate risk, often requires 510(k)), and Class III (high risk, requires PMA).
- EU MDR: Class I (low risk), Class IIa (moderate risk), Class IIb (higher risk), and Class III (high risk, requires rigorous clinical evaluation and certification by a Notified Body).
9. What are the main differences between FDA and EU MDR regulatory requirements?
While both emphasize patient safety, key differences include:
- FDA: Primarily focuses on pre-market clearance (510(k), PMA) and post-market reporting.
- EU MDR: Requires a stricter lifecycle approach with comprehensive clinical evidence, more stringent post-market surveillance, and involvement of Notified Bodies even for moderate-risk devices.
10. How do I ensure my device meets EU MDR General Safety and Performance Requirements (GSPR)?
To comply with GSPR, manufacturers must:
- Perform a risk assessment per ISO 14971.
- Conduct clinical evaluation and performance testing.
- Ensure appropriate labeling, IFU, and technical documentation.
- Implement a robust post-market surveillance plan.
11. What is the role of Notified Bodies in EU MDR compliance?
Notified Bodies (NBs) are independent organizations designated by EU authorities to assess medical device compliance. For Class IIa, IIb, and III devices, NBs review technical documentation, conduct audits, and issue CE certifications.
12. What happens if my medical device is not compliant with regulatory standards?
Non-compliance can result in:
- Market entry delays or rejections.
- Product recalls, fines, or legal action.
- Reputational damage and loss of customer trust. Ensuring early compliance with FDA, EU MDR, and ISO standards minimizes these risks.
Why Choose ADRES?
With extensive experience in the medical device industry, ADRES delivers tailored regulatory and quality solutions that streamline compliance, reduce risks, and accelerate market entry. Our expertise ensures that your medical devices meet the highest safety and performance standards worldwide.
Get Started Today
Let us help you navigate the complexities of medical device regulations. Contact us to discuss your compliance needs and develop a strategic approach for your medical device approvals.